Leuven University Centre for Sleep and wake disord, University Hospitals Leuven


Bertien Buyse
Herestraat 49, 3000
+ 32 16 342522
+ 32 16 342528
Research Domain
  • Clinical
  • Sleep and Body Functions (Cardio-Respiratory, Thermoregulation/Metabolism, Endocrine)
  • Neurological Sleep Disorders
  • Sleep and Medical Disorders

Laboratory description

– Hypoventilation in neuromuscular disorders
– OSA and transplantation
– OSA and pulmonary hypertension

Technical Capabilities and areas of expertise

– Video-PSG and nocturnal CO2 monitoring
– Full PSG NIV monitoring
– Ventilatory drive and lung function
– Endothelial dysfunction
– Heart rate variability
– Activity measurement

Selected Publications in the 5 past years:

– Upper Airway Obstruction during Noninvasive Ventilation Induced by the Use of an Oronasal Mask. Vrijsen B, Buyse B, Belge C, Testelmans D. J Clin Sleep Med. 2014 Sep 15;10(9):1033-5.

– Diaphragm plication for unilateral diaphragm paralysis: a case report and review of the literature. Declerck S, Testelmans D, Nafteux P, Coosemans W, Belge C, Decramer M, Buyse B, Buyse B. Acta Clin Belg. 2013 Jul-Aug;68(4):311-5. Review.

– Sleep apnea classification using least-squares support vector machines on single lead ECG. Varon C, Testelmans D, Buyse B, Suykens JA, Van Huffel S. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:5029-32.

– Pathological breathing patterns after pneumococcal rhombencephalitis. Muyldermans S, Vrijsen B, Decramer M, Belge C, Testelmans D, Buyse B. Respir Care. 2014 May;59(5):e84-8.

– Profile of circulating cytokines: impact of OSA, obesity and acute cardiovascular events. Testelmans D, Tamisier R, Barone-Rochette G, Baguet JP, Roux-Lombard P, Pépin JL, Lévy P.
Cytokine. 2013 May;62(2):210-6.

– Robust artefact detection in long-term ECG recordings based on autocorrelation function similarity and percentile analysis. Varon C, Testelmans D, Buyse B, Suykens JA, Van Huffel S. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:3151-4.

– Non-invasive ventilation in amyotrophic lateral sclerosis. Vrijsen B, Testelmans D, Belge C, Robberecht W, Van Damme P, Buyse B. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Mar;14(2):85-95.

– Time to stop counting sheep in the ICU. Testelmans D, Vrijsen B, Buyse B. Crit Care Med. 2013 Jan;41(1):338-9.

– Diaphragm activity during mechanical ventilation: a narrow therapeutic margin. Testelmans D, Decramer M. Crit Care Med. 2012 Apr;40(4):1375-6.

– Treating primary insomnia: clinical effectiveness and predictors of outcomes on sleep, daytime function and health-related quality of life. Van Houdenhove L, Buyse B, Gabriëls L, Van den Bergh O.
J Clin Psychol Med Settings. 2011 Sep;18(3):312-21.

– Cognitive-behavioural therapy for primary insomnia: effectiveness in a clinical setting. Van Houdenhove L, Buyse B, Gabriels L, Van Diest I, Van den Bergh O. Tijdschr Psychiatr. 2010;52(2):79-88.

Key Publications of the Laboratory:

– Treatment of chronic respiratory failure in kyphoscoliosis: oxygen or ventilation? Buyse B, Meersseman W, Demedts M.
Eur Respir J. 2003 Sep;22(3):525-8.

– Effect of obesity and/or sleep apnea on chemosensitivity: differences between men and women. Buyse B, Markous N, Cauberghs M, Van Klaveren R, Muls E, Demedts M.
Respir Physiol Neurobiol. 2003 Feb 19;134(1):13-22.

– Atrophy and hypertrophy signalling in the diaphragm of patients with COPD. Testelmans D, Crul T, Maes K, Agten A, Crombach M, Decramer M, Gayan-Ramirez G. Eur Respir J. 2010 Mar;35(3):549-56.

Current/Completed Grants (past 5 years):

– 2011: Belgian Association for Neuromuscular Disorders for “Monitoring of non-invasive ventilation during sleep in amyotrophic lateral sclerosis: what can be learned from full polysomnography with incorporation of transcutaneous CO2 monitoring and built-in ventilator software?”

– 2014 Funding Fonds Annie Planckaert-Dewaele for “Research on sleep disordered breathing in pulmonary hypertension (ZAP-KOOR initiative)

Other laboratory Members

Title:  PhD MD

Name:  Dries Testelmans

Position:  Pulmonologist

Email:  dries.testelmans@uzleuven.be

Title:  PhD MD

Name:  Catharina Belge

Position:  Pulmonologist

Email:  catharina.belge@uzleuven.be

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