London Sleep Centre

Sleep Medicine

Irshaad Ebrahim
Medical Director
137 Harley Street, W1G 6BF
United Kingdom
+44 20 77250523
+44 20 77250524
Research Domain
  • Clinical
  • Learning, Memory, Cognition
  • Sleep and Medical Disorders
  • Pharmacology of Sleep
  • Sleep and Ageing
  • Sleep and Psychiatry-Personality Disorders
  • Sleep Physiology-Neurophysiology in Human
  • Behavioural Sleep Disorders
  • Neurological Sleep Disorders

Laboratory description

The London Sleep Centre provides comprehensive clinical and research services for the entire London and South-East Region of England. We have a track record of Clinical Research in all aspects of Sleep Disorders.

Technical Capabilities and areas of expertise

We are able to conduct full laboratory studies for Humans from Phase 2 to Phase 4.

Additional Descriptors, Keywords

We have a second Clinical and Research Site in the UK based in Edinburgh, Scotland –

Selected Publications in the 5 past years:

1. Ebrahim IO. The Management of Excessive Daytime Sleepiness. Drugs & Therapeutics Bulletin. 2004 June;

2. Nightingale S, Williams AJ, Orgill JC, Ebrahim IO, de Lacy S. The association between narcolepsy and REM behaviour disorder (RBD) Sleep Medicine (2005)

3. Ebrahim IO, Peacock KW. REM Sleep Behavior Disorder – Psychiatric Presentations: A Case Series from the United Kingdom Journal of Clinical Sleep Medicine, Vol. 1, No. 1, 2005

4. Ebrahim IO, Peacock KW, Williams AJ. Post-traumatic Narcolepsy: 2 case reports and a mini-review. Journal of Clinical Sleep Medicine, Vol. 1, No. 2, 2005

5. Ebrahim IO, Williams AJ, Peacock KW, Maldonado CC. Driver Sleepiness in South African Commercial Drivers: A two stage screening study. SLEEP 28: 165 (2005)

6. Ebrahim IO, de Lacy S, et al. CSF Hypocretin (Orexin) in disorders of excessive daytime sleepiness. SLEEP 28: 216 (2005)

7. Wilson W, Ebrahim IO, Fenwick P, Marks RL. Violence, Sleepwalking and the Criminal Law. Criminal Law Review (August 2005)

8. Ebrahim IO, Wilson W, Fenwick PB, Peacock KW, Marks RL. Sleep related violence, Alcohol, Automatism and the Law. Criminal Law Review (2005)

9. Ioannides AA, Fenwick PB. Imaging cerebellum activity in real time with magnetoencephalographic data. Prog Brain Res. 2005;148:139-50. Review.

10. Ioannides AA, Fenwick PB, Liu L. Widely distributed magnetoencephalography spikes related to the planning and execution of human saccades. J Neurosci. 2005 Aug 31;25(35):7950-67.

11. Ebrahim IO. Somnambulistic Sexual Behaviour (Sexsomnia). Journal of Clinical Forensic Medicine 13 (2006) 219–224

35. A. Ioannides, M. Corsi-Cabrera, P. Fenwick,, et al. Magnetic field tomography of both cortical and pontine activity during eye movements Clinical Neurophysiology, February 2007

12. Hajak G, Ebrahim IO, Vincent S & Hibberd M. Ramelteon, unlike Zopiclone, has no Effect on Body Sway at Peak Plasma Levels in Insomnia Patients. SLEEP (2007)

Key Publications of the Laboratory:

1. Clarke NA, Williams AJ, Kopelman MD: REM Behaviour Disorder in Dementia. Br J Psych. Vol 176: 189-192, 2000.

2. Lawrence E, Dundas R, Higgens SE, Howard R, Rudd AG, Wolfe C, Williams AJ. The natural history and associations of sleep-disordered breathing in first ever stroke. Internat J Clin Practice 55: 584-588, 2001

3. Ebrahim IO, The three faces of Memory Disorder; Health and Aging, 2000, 14:24 -27;

4. Oka Y, Howard RS, Williams AJ. Review of REM Sleep Behaviour Disorder in a Sleep Disorder Centre in the United Kingdom. J Neurol. Sci 2001; 187: P1563.

5. Williams AJ, Higgins SE, Howard RS. Assessment of Sleepiness in a Clinic Population – the Value {or not} of the Multiple Sleep Latency Test {MSLT} J Neurol. Sci 2001; 187: P1568.

6. Nooman YM, Seers C, Higgins SE, Seed P, Howard RS, Williams AJ. Assessment of Heart Rate Variability During Periodic Limb Movements in Sleep. J Neurol. Sci 2001; 187: P1570.

7. Sam Parnia, D. G. Waller, R. Yeates and P. Fenwick. A qualitative and quantitative study of the incidence, features and aetiology of near death experiences in cardiac arrest survivors. Resuscitation, Volume 48, Issue 2, February 2001

8. Ebrahim IO, Howard R S, Kopelman M D, Sharief M K, and Williams A J. The hypocretin/orexin system. J R Soc Med 2002 95: 227-230;

9. Ebrahim IO, de Lacy S, Semra Y K, Howard R S, Sharief M K, and Williams AJ. CSF Hypocretin levels in Neurologic and Psychiatric conditions, SLEEP 2002;

10. Ebrahim IO, de Lacy S, Semra Y K, Howard R S, Sharief M K, and Williams A J. Narcolepsy with cataplexy, Monosymptomatic Narcolepsy and Primary Hypersomnia: A prospective study in 24 patients including CSF hypocretin levels, SLEEP 2002; 25:

11. Ebrahim IO, Memory Disorders in Psychiatric Practice, BJPsych 2002; 181: 177-178;

12. Ebrahim IO, Sharief MK, de Lacy S, Semra YK, Howard RS, Kopelman MD, Williams AJ. Hypocretin (Orexin) Deficiency in Narcolepsy and Primary Hypersomnia. JNNP 2003; 74(1): 127-130;

13. Ebrahim IO, Williams AJ, et al. CSF Hypocretin (Orexin) in Neurological and Psychiatric disorders. JSR 2003; 12(1).

14. Nooman YM, Seers C, Higgins SE, Howard RS, Williams AJ. The Use of Heart Rate Variability to differentiate between obstructive and non-obstructive sleep apnoea. Am J Resp Crit Care Med.

15. L. C. Liu, P. B. C. Fenwick, et al. The human primary somatosensory cortex response contains components related to stimulus frequency and perception in a frequency discrimination task. Neuroscience, Volume 121, Issue 1, 26 September 2003

16. Ebrahim IO, Fisher JP, de Lacy S, Williams AJ. A prospective, randomized, trial comparing the effectiveness of Cognitive Behaviour Therapy, Pharmacologic Treatment and Combination therapy in patients with Primary Insomnia. SLEEP (2003)

17. Williams AJ, Oka Y, Howard RS, Soliman MGG, de Lacy S, Ebrahim IO REM Sleep Behaviour Disorder – Characteristics of a series of consecutive referrals to a Specialist Sleep disorders Centre in the UK, SLEEP (2003)

18. Ebrahim IO, de Lacy S, Howard RS, Sharief MK, Williams AJ. CSF Hypocretin (Orexin) in Disorders of Excessive Daytime Sleepiness. SLEEP (2003).

19. Nightingale S, Orgill JC, Ebrahim IO, Williams AJ. The Association between Narcolepsy and REM Sleep Behaviour Disorder (RBD). SLEEP (2004)

20. Thannickal TC, Mayhew J Blouin A, Nienhuis R, Williams AJ, Ebrahim IO, Siegel JM. Distribution of Hypocretin (Orexin) Immunoreactivity In The Hypothalamus Of Normal And Narcoleptic Horse. SLEEP (2004)

21. Orgill JC, Bath J, Ebrahim IO, de Lacy SF, Williams AJ. The role of Actigraphy in the study of Sleep and Circadian Rhythms. SLEEP (2004).

22. Y. Nagai, H. D. Critchley, E. Featherstone, P. B. C. Fenwick, M. R. Trimble and R. J. Dolan. Brain activity relating to the contingent negative variation: an fMRI investigation NeuroImage, Volume 21, Issue 4, April 2004,

23. Nagai Y, Goldstein LH, Critchley HD, Fenwick PB. Influence of sympathetic autonomic arousal on cortical arousal: implications for a therapeutic behavioural intervention in epilepsy. Epilepsy Res. 2004 Feb;58(2-3):185-93.

Other laboratory Members

Title:  PhD

Name:  Christopher Idzikowski

Position:  Research Director Edinburgh Sleep Centre


Title:  MD

Name:  Adrian Williams

Position:  Professor of Sleep Medicine


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